36
M. Z. Goldani et al., “Cesarean Section and Increased Body Mass Index in School Children: Two Cohort Studies from Distinct Socioeconomic Background Areas in Brazil,” Nutrition Journal 12, no. 1 (July 25, 2013): 104; A. A. Mamun et al., “Cesarean Delivery and the Long-term Risk of Offspring Obesity,” Obstetrics and Gynecology 122, no. 6 (December 2013): 1176–83; D. N. Mesquita et al., “Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study,” PloS One 8, no. 6 (June 27, 2013): e66827; K. Flemming et al., “The Association Between Caesarean Section and Childhood Obesity Revisited: A Cohort Study,” Archives of Disease in Childhood 98, no. 7 (July 2013): 526–32; E. Svensson et al., “Caesarean Section and Body Mass Index Among Danish Men,” Obesity 21, no. 3 (March 2013): 429–33; H. T. Li, Y. B. Zhou, and J. M. Liu, “The Impact of Cesarean Section on Offspring Overweight and Obesity: A Systematic Review and Meta-Analysis,” International Journal of Obesity 37, no. 7 (July 2013): 893–99; H. A. Goldani et al., “Cesarean Delivery Is Associated with an Increased Risk of Obesity in Adulthood in a Brazilian Birth Cohort Study,” American Journal of Clinical Nutrition 93, no. 6 (June 2011): 1344–47; L. Zhou et al., “Risk Factors of Obesity in Preschool Children in an Urban Area in China,” European Journal of Pediatrics 170, no. 11 (November 2011): 1401–6.
37
T. Marrs et al., “Is There an Association Between Microbial Exposure and Food Allergy? A Systematic Review,” Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 24, no. 4 (June 2013): 311–20 e8.
38
J. Penders et al., “Establishment of the Intestinal Microbiota and Its Role for Atopic Dermatitis in Early Childhood,” Journal of Allergy and Clinical Immunology 132, no. 3 (September 2013): 601–7 e8; K. Pyrhonen et al., “Caesarean Section and Allergic Manifestations: Insufficient Evidence of Association Found in PopulationBased Study of Children Aged 1 to 4 Years,” Acta Paediatrica 102, no. 10 (October 2013): 982–89; F. A. van Nimwegen et al., “Mode and Place of Delivery, Gastrointestinal Microbiota, and Their Influence on Asthma and Atopy,” Journal of Allergy and Clinical Immunology 128, no. 5 (November 2011): 948–55 e1–3; P. Bager, J. Wohlfahrt, and T. Westergaard, “Caesarean Delivery and Risk of Atopy and Allergic Disease: Meta-Analyses,” Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology 38, no. 4 (April 2008): 634–42; K. Negele et al., “Mode of Delivery and Development of Atopic Disease During the First 2 Years of Life,” Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 15, no. 1 (February 2004): 48–54.
39
M. B. Azad et al., “Gut Microbiota of Healthy Canadian Infants: Profiles by Mode of Delivery and Infant Diet at 4 Months,” CMAJ: Canadian Medical Association Journal 185, no. 5 (March 19, 2013): 385–94.
40
J. E. Koenig et al., “Succession of Microbial Consortia in the Developing Infant Gut Microbiome,” supplement 1, Proceedings of the National Academy of Sciences of the United States of America 108 (March 15, 2011): 4578–85.
41
G. D. Wu et al., “Linking Longterm Dietary Patterns with Gut Microbial Enterotypes,” Science 334, no. 6052 (October 7, 2011): 105–8.
42
G. D. Wu et al., “Linking Longterm Dietary Patterns with Gut Microbial Enterotypes,” Science 334, no. 6052 (October 7, 2011): 105–8.
43
J. Qin et al., “A Human Gut Microbial Gene Catalogue Established by Metagenomic Sequencing,” Nature 464, no. 7285 (March 4, 2010): 59–65.
44
T. Yatsunenko et al., “Human Gut Microbiome Viewed Across Age and Geography,” Nature 486, no. 7402 (May 9, 2012): 222–7.
45
J. H. Hehemann et al., “Transfer of Carbohydrate-Active Enzymes from Marine Bacteria to Japanese Gut Microbiota,” Nature 464, no. 7290 (April 8, 2010): 908–12.
46
P. J. Turnbaugh et al., “A Core Gut Microbiome in Obese and Lean Twins,” Nature 457, no. 7228 (Jan. 22, 2009): 480–4.
47
J. Genuneit et al., “The Combined Effects of Family Size and Farm Exposure on Childhood Hay Fever and Atopy,” Pediatric Allergy and Immunology: Official Publication of the European Society of Pediatric Allergy and Immunology 24, no. 3 (May 2013): 293–98.
48
S. J. Song et al., “Cohabiting Family Members Share Microbiota with One Another and with Their Dogs,” eLife 2 (April 16, 2013): e00458.
49
J. G. Caporaso et al., “Moving Pictures of the Human Microbiome,” Genome Biology 12, no. 5 (2011): R50.
50
M. J. Claesson et al., “Gut Microbiota Composition Correlates with Diet and Health in the Elderly,” Nature 488, no. 7410 (August 9, 2012): 178–84.
51
P. J. Turnbaugh et al., “DietInduced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome,” Cell Host & Microbe 3, no. 4 (April 17, 2008): 213–23.
52
M. Vijay-Kumar et al., “Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-like Receptor 5,” Science 328, no. 5975 (April 9, 2010): 228–31.
53
Ridaura et al., “Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice.”
54
D. Mozaffarian et al., “Changes in Diet and Lifestyle and Long-term Weight Gain in Women and Men,” New England Journal of Medicine 364, no. 25 (June 23, 2011): 2392–404.
55
L. A. David et al., “Diet Rapidly and Reproducibly Alters the Human Gut Microbiome,” Nature 505, no. 7484 (January 23, 2014): 559–63.
56
D. P. Strachan, “Hay Fever, Hygiene, and Household Size,” British Medical Journal 299, no. 6710 (Nov. 18, 1989): 1259–60.
57
D. P. Strachan, “Is Allergic Disease Programmed in Early Life?”, Clinical & Experimental Allergy 24, no. 7 (July 1994): 603–5.
58
J. Riedler et al., “Exposure to Farming in Early Life and Development of Asthma and Allergy: A Cross-Sectional Study,” The Lancet 358, no. 9288 (Oct. 6, 2001): 1129–33.
59
S. Illi et al., “Protection from Childhood Asthma and Allergy in Alpine Farm Environments – the GABRIEL Advanced Studies,” Journal of Allergy and Clinical Immunology 129, no. 6 (June 2012): 1470–7.
60
Braun-Fahrländer et al., “Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children,” New England Journal of Medicine 347, no. 12 (Sept. 19, 2002): 869–77.
61
J. Douwes et al., “Does Early Indoor Microbial Exposure Reduce the Risk of Asthma? The Prevention and Incidence of Asthma and Mite Allergy Birth Cohort Study,” Journal of Allergy and Clinical Immunology 117, no. 5 (May 2006): 1067–73.
62
S. Lau et al., “Early Exposure to House-Dust Mite and Cat Allergens and Development of Childhood Asthma: a Cohort Study. Multicenter Allergy Study Group,” The Lancet 356, no. 9239 (Oct. 21, 2000): 1392–7.
63
M. J. Ege et al., “Exposure to Environmental Microorganisms and Childhood Asthma,” New England Journal of Medicine 364, no. 8 (Feb. 24, 2011): 701–9.
64
E. Y. Hsiao et al., “Microbiota Modulate Behavioral and Physiological Abnormalities Associated With Neurodevelopmental Disorders,” Cell 155, no. 7 (Dec. 19, 2013): 1451–63.
65
N. Elazab et al., “Probiotic Administration in Early Life, Atopy, and Asthma: a Meta-Analysis of Clinical Trials,” Pediatrics 132, no. 3 (Sept. 2013): 666–76.
66
A. A. Niccoli et al., “Preliminary Results on Clinical Effects of Probiotic Lactobacillus Salivarius LS01 in Children Affected by Atopic Dermatitis,” Journal of Clinical Gastroenterology 48, supplement 1 (Nov-Dec 2014): S34–6.
67
M. C. Arrieta and B. Finlay, “The Intestinal Microbiota and Allergic Asthma,” Journal of Infection 4453, no. 14 (Sept. 25, 2014): 227–8.
68
A. Du Toit, “Microbiome: Clostridia Spp. Combat Food Allergy in Mice,” National Review of Microbiology 12, no. 10 (Sept. 16, 2014): 657.
69
A. T. Stefka et al., “Commensal Bacteria Protect Against Food Allergen Sensitization,” Proceedings of the National Academy of Sciences 111, no. 36 (Sept. 9, 2014): 13145–50.
70
M. Noval Rivas et al., “A Microbiota Signature Associated With Experimental Food Allergy Promotes Allergic Sensitization and Anaphylaxis,” Journal of Allergy and Clinical Immunology 131, no. 1 (Jan. 2013): 201–12.
71
M. S. Kramer et al., “Promotion of Breastfeeding Intervention Trial (PROBIT): a ClusterRandomized Trial in the Republic of Belarus. Design, Follow-Up, and Data Validation,” Advances in Experimental Medicine and Biology 478 (2000): 327–45.
72
H. Kronborg et al., “Effect of Early Postnatal Breastfeeding Support: a Cluster-Randomized Community Based Trial,” Acta Pediatrica 96, no. 7 (July 2007): 1064–70.
73
I. Hanski et al., “Environmental Biodiversity, Human Microbiota, and Allergy Are Interrelated,” Proceedings of the National Academy of Sciences 109, no. 21 (May 22, 2012): 8334–9.
74
C. G. Carson, “Risk Factors for Developing Atopic Dermatitis,” Danish Medical Journal 60, no. 7 (July 2013): B4687.
75
E. von Mutius et al., “The PASTURE Project: E. U. Support for the Improvement of Knowledge About Risk Factors and Preventive Factors for Atopy in Europe,” Allergy 61, no. 4 (April 2006): 407–13.
76
S. J. Song et al., “Cohabiting Family Members Share Microbiota With One Another and With Their Dogs,” eLife 2 (April 16, 2013).
77
B. Brunekreef et al., “Exposure to Cats and Dogs, and Symptoms of Asthma, Rhinoconjunctivitis, and Eczema,” Epidemiology 23, no. 5 (Sept. 2012): 742–50.
78
I. Trehan et al., “Antibiotics as Part of the Management of Severe Acute Malnutrition,” New England Journal of Medicine 368, no. 5 (January 31, 2013): 425–35.
79
M. I. Smith et al., “Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor,” Science 339, no. 6119 (February 1, 2013): 548–54.
80
Turnbaugh et al., “Core Gut Microbiome in Obese and Lean Twins.”
81
D. N. Frank et al., “MolecularPhylogenetic Characterization of Microbial Community Imbalances in Human Inflammatory Bowel Diseases,” Proceedings of the National Academy of Sciences of the United States of America 104, no. 34 (August 21, 2007): 13780–85; M. Tong et al., “A Modular Organization of the Human Intestinal Mucosal Microbiota and Its Association with Inflammatory Bowel Disease,” PloS One 8, no. 11 (November 19, 2013): e80702.
82
J. U. Scher et al., “Expansion of Intestinal Prevotella Copri Correlates with Enhanced Susceptibility to Arthritis,” eLife 2 (November 5, 2013): e01202.
82
J. U. Scher et al., “Expansion of Intestinal Prevotella Copri Correlates with Enhanced Susceptibility to Arthritis,” eLife 2 (November 5, 2013): e01202.
83
P. Bercik, “The MicrobiotaGut-Brain Axis: Learning from Intestinal Bacteria?”, Gut 60, no. 3 (March 2011): 288–89.
84
J. F. Cryan and S. M. O’Mahony, “The Microbiome-Gut-Brain Axis: From Bowel to Behavior,” Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society 23, no. 3 (March 2011): 187–92.
85
A. Naseribafrouei et al., “Correlation Between the Human Fecal Microbiota and Depression,” Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society 26, no. 8 (August 2014): 1155–62.
86
G. A. Rook, C. L. Raison, and C. A. Lowry, “Microbiota, Immunoregulatory Old Friends and Psychiatric Disorders,” Advances in Experimental Medicine and Biology 817 (2014): 319–56.
87
D. W. Kang et al., “Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children,” PLoS One 8, no. 7 (2013): e68322.
88
Hsiao et al., “Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders.”
89
Vijay-Kumar et al., “Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Tolllike Receptor 5.”
90
P. Bercik et al., “The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice,” Gastroenterology 141, no. 2 (August 2011): 599–609, 609 e1–3.
91
R. Diaz Heijtz et al., “Normal Gut Microbiota Modulates Brain Development and Behavior,” Proceedings of the National Academy of Sciences of the United States of America 108, no. 7 (February 15, 2011): 3047–52.
92
C. L. Ohland et al., “Effects of Lactobacillus Helveticus on Murine Behavior Are Dependent on Diet and Genotype and Correlate with Alterations in the Gut Microbiome,” Psychoneuroendocrinology 38 (2013): 1738–47.
93
A. R. Mackos et al., “Probiotic Lactobacillus Reuteri Attenuates the Stressor-Enhanced Sensitivity of Citrobacter Rodentium Infection,” Infection and Immunity 81, no. 9 (September 2013): 3253–63.
94
P. A. Kantak, D. N. Bobrow, and J. G. Nyby, “Obsessive-Compulsive-like Behaviors in House Mice Are Attenuated by a Probiotic (Lactobacillus Rhamnosus GG),” Behavioural Pharmacology 25, no. 1 (February 2014): 71–79.
95
Hsiao et al., “Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders.”
96
S. Guandalini et al., “VSL#3 Improves Symptoms in Children with Irritable Bowel Syndrome: A Multicenter, Randomized, Placebo-Controlled, DoubleBlind, Crossover Study,” Journal of Pediatric Gastroenterology and Nutrition 51, no. 1 (July 2010): 24–30.
97
M. Dapoigny et al., “Efficacy and Safety Profile of LCR35 Complete Freeze-Dried Culture in Irritable Bowel Syndrome: A Randomized, Double-Blind Study,” World Journal of Gastroenterology 18, no. 17 (May 7, 2012): 2067–75.
98
E. Smecuol et al., “Exploratory, Randomized, Double-Blind, Placebo-Controlled Study on the Effects of Bifidobacterium Infantis Natren Life Start Strain Super Strain in Active Celiac Disease,” Journal of Clinical Gastroenterology 47, no. 2 (February 2013): 139–47.
99
M. Fr mont et al., “HighThroughput 16S rRNA Gene Sequencing Reveals Alterations of Intestinal Microbiota in Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome Patients,” Anaerobe 22 (August 2013): 50–56.
100
M. Messaoudi et al., “Beneficial Psychological Effects of a Probiotic Formulation (Lactobacillus Helveticus R0052 and Bifidobacterium Longum R0175) in Healthy Human Volunteers,” Gut Microbes 2, no. 4 (July/August 2011): 256–61.
101
Medical Council, General Board of Health, Report of the Committee for Scientific Inquiries in Relation to the Cholera-Epidemic of 1854 (London, England, 1855).
102
C. A. Lozupone et al., “Diversity, Stability and Resilience of the Human Gut Microbiota,” Nature 489, no. 7415 (September 13, 2012): 220–30.
103
S. H. Duncan et al., “Contribution of Acetate to Butyrate Formation by Human Faecal Bacteria,” British Journal of Nutrition 91 (2004): 915–23.
104
World Gastroenterology Organisation, World Gastroenterology Organisation Practice Guideline: Probiotics and Prebiotics (May 2008). www.worldgastroenterology.org/assets/downloads/en/pdf/guidelines/19_probiotics_prebiotics.pdf.
105
Чтобы вы могли получить представление о результатах клинических испытаний: в перекрестном, плацебоконтролируемом, двойном слепом исследовании потребление 30 граммов в день пребиотика под названием изомальт (смесь полиолов 1-О-Dглюкопиранозила-D-маннитола и 6-О-D-глюкопиранозила-Dсорбитаола) в течение четырех недель привело к увеличению доли бифидобактерий на 65 процентов и увеличению общего количества их клеток на 47 процентов по сравнению с потреблением сахарозы. Другими словами, этот пребиотик увеличил количество представителей вида бактерий, который считается полезным, хотя прямое его воздействие на функции кишечника не изучалось. В другом исследовании, где двенадцать добровольцев принимали по 10 граммов инулина в день в течение шестнадцати дней, доля бактерий вида Bifidobacterium adolescentis увеличилась с 0,89 до 3,9 процента от общего количества микробов по сравнению с контрольным периодом без каких-либо пищевых добавок. A. Gostner, “Effect of Isomalt Consumption on Faecal Microflora and Colonic Metabolism in Healthy Volunteers,” British Journal of Nutrition 95, no. 1 (January 2006): 40–50; C. Ramirez-Farias et al., “Effect of Inulin on the Human Gut Microbiota: Stimulation of Bifidobacterium Adolescentis and Faecalibacterium Prausnitzii,” British Journal of Nutrition 101, no. 4 (February 2009): 541–50.
106
H. Steed et al., “Clinical Trial: The Microbiological and Immunological Effects of Synbiotic Consumption – A Randomized Double-Blind Placebo-Controlled Study in Active Crohn’s Disease,” Alimentary Pharmacology & Therapeutics 32, no. 7 (October 2010): 872–83.
107
D. Linetzky Waitzberg, “Microbiota Benefits After Inulin and Partially Hydrolized Guar Gum Supplementation: A Randomized Clinical Trial in Constipated Women,” Nutricion Hospitalaria 27, no. 1 (January/February 2012): 123–29.
108
Z. Asemi et al., “Effects of Synbiotic Food Consumption on Metabolic Status of Diabetic Patients: A Double-Blind Randomized Crossover Controlled Clinical Trial,” Clinical Nutrition 33, no. 2 (April 2014): 198–203.
109
J. A. Applegate et al., “Systematic Review of Probiotics for the Treatment of Community-Acquired Acute Diarrhea in Children,” supplement 3, BMC Public Health 13 (2013): S16.
110
A. P. Hungin et al., “Systematic Review: Probiotics in the Management of Lower Gastrointestinal Symptoms in Clinical Practice – An Evidence-Based International Guide,” Alimentary Pharmacology & Therapeutics 38, no. 8 (October 2013): 864–86.
111
N. P. McNulty et al., “The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins,” Science Translational Medicine 3, no. 106 (October 26, 2011): 106ra106.
112
H. J. Kim et al., “A Randomized Controlled Trial of a Probiotic Combination VSL# 3 and Placebo in Irritable Bowel Syndrome with Bloating,” Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society 17, no. 5 (October 2005): 687–96.
113
D. J. Merenstein, J. Foster, and F. D’Amico, “A Randomized Clinical Trial Measuring the Influence of Kefir on Antibiotic-Associated Diarrhea: The Measuring the Influence of Kefir (MILK) Study,” Archives of Pediatrics & Adolescent Medicine 163, no. 8 (August 2009): 750–54; R. S. Beniwal, “A Randomized Trial of Yogurt for Prevention of Antibiotic-Associated Diarrhea,” Digestive Diseases and Sciences 48, no. 10 (October 2003): 2077–82.
114
“Clostridium Difficile Fact Sheet,” Centers for Disease Control and Prevention, accessed September 2014, www.cdc.gov/hai/eip/pdf/Cdiff-factsheet.pdf.
115
I. Youngster, “Fecal Microbiota Transplant for Relapsing Clostridium Difficile Infection Using a Frozen Inoculum from Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study,” Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 58, no. 11 (June 1, 2014): 1515–22; Z. Kassam et al., “Fecal Microbiota Transplantation for Clostridium Difficile Infection: Systematic Review and MetaAnalysis,” American Journal of Gastroenterology 108, no. 4 (April 2013): 500–508.
116
“How Well Do Vaccines Work?”, Vaccines. gov, US Department of Health and Human Services, accessed October 11, 2014, www.vaccines.gov/basics/effectiveness.
117
“Vaccines • Disease,” Immunization Healthcare Branch, accessed October 11, 2014, www.vaccines.mil/Vaccines.
118
Y. Li et al., “On the Origin of Smallpox: Correlating Variola Phylogenics with Historical Smallpox Records,” Proceedings of the National Academy of Sciences of the United States of America 104, no. 40 (October 2, 2007): 15787–92.
119
Rob Stein, “Should Last Remaining Known Smallpox Virus Die?”, Washington Post, March 8, 2011.
120
Z. Wang et al., “Gut Flora Metabolism of Phosphatidylcholine Promotes Cardiovascular Disease,” Nature 472, no. 7341 (April 7, 2011): 57–63.
121
A. D. Kostic et al., “Genomic Analysis Identifies Association of Fusobacterium with Colorectal Carcinoma,” Genome Research 22, no. 2 (February 2012): 292–98.
122
Ley, “Microbial Ecology.”
123
C. A. Lowry et al., “Identification of an Immune-Responsive Mesolimbocortical Serotonergic System: Potential Role in Regulation of Emotional Behavior,” Neuroscience 146, no. 2 (May 11, 2007): 756–72.
124
G. A. Rook, C. L. Raison, and C. A. Lowry, “Can We Vaccinate Against Depression?”, Drug Discovery Today 17, nos. 9–10 (May 2012): 451–58.
125
“Conjunctivitis (Pink Eye) in Newborns,” Centers for Disease Control and Prevention, accessed October 11, 2014, www.cdc.gov/conjunctivitis/newborns.html.